Английски език
Nifedipine acts as a calcium channel blocker which shows therapeutic values against Hypertension, Angina, and other Cardiac diseases. New Drug Delivery System recently applied in therapeutic use with the relevant formulation of microsphere for sustained release properties. Delivered drugs are absorbed uniformly safely and effective blood level of Nifedipine can be maintained for prolonged time. The present study is to investigate the possibility of developing fingerprinting characteristic of Nifedipine Microsphere by using combined polymer (Ethylcellulose, Polyvinylalcohol) in different proportions required in the formulation of Microsphere for Sustained Release Medication. Solvent evaporation method was used for preparation of Microsphere containing Nifedipine, taking Ethyl cellulose as polymer. The preformulation study was carried out through Uv-Visible spectrophotometer for the identification of maximum absorbance of the drug. Identification of functional group frequencies with the help of Fourier Transform Infrared Spectroscopy has been made.
