Anaphase promoting complex: structure and expression

Name: Anaphase promoting complex: structure and expression
Brand: LAP Lambert Academic Publishing
SKU: 9783659875595
Price: 59.4 EUR
Availability: InStock

Автор: Hamzeh Rahimi

Език:

Корици: С меки корици

Издател: LAP Lambert Academic Publishing

Наличност: Външен склад

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The anaphase promoting complex (APC) is the largest Cullin-RING E3 ligase that plays a critical role...

Информация за книгата

Автор

Hamzeh Rahimi

Език

Английски език

Корици

Книга - С меки корици

Издадена

2016

страници

184

EAN

9783659875595

Enbook ID

14441403

Издател

LAP Lambert Academic Publishing

Теглоt

290

Размери

150 x 220 x 11

Пълно описание

The anaphase promoting complex (APC) is the largest Cullin-RING E3 ligase that plays a critical role in cell cycle control and known as target of anti-cancer agents. APC regulates the onset of chromosome separation and mitotic exit via securin and cyclin B degradation, respectively. APC controls this process by mediating ubiquitin conjugation to substrates such as cyclin B and securin. The objective of this study was to evaluate the expression pattern of APC subunits in cancer cell lines and AML patients. Moreover, inhibitory compounds were designed based on the 3D structure of the APC and their inhibitory effects were investigated on HeLa and MDA-MB-435 cell lines. To do this, the 3D structure of APC was predicted using homology modelling and molecular dynamic simulation. Interaction among APC subunits were studied by using protein-protein docking methods. It was found that catalytic subunits of APC over-expressed in cancer cell lines and AML patients. Furthermore, the APC subunits assembly and activation was demonstrated at the atomic-level.

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Anaphase promoting complex: structure and expression

Информация за книгата

Пълно описание

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