Anticancer Drug Resistance

Name: Anticancer Drug Resistance
Brand: Springer, Berlin
SKU: 9780792328360
Price: 209.83 EUR
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Advances in Molecular and Clinical Research

Автор: Lori J. Goldstein, Robert F. Ozols

Език:

Корици: С твърди корици

Издател: Springer, Berlin

Наличност: Външен склад

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Over the last 50 years, drug development and clinical trials have resulted in successful complete re...

Информация за книгата

Автор

Lori J. Goldstein, Robert F. Ozols

Език

Английски език

Корици

Книга - С твърди корици

Издадена

1994

страници

294

EAN

9780792328360

ISBN

0792328361

Enbook ID

05250147

Издател

Springer, Berlin

Теглоt

688

Размери

160 x 235 x 24

Пълно описание

Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with over 500,000 cancer-related deaths per year. Clearly, the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation. §Since the last volume in this series, we have learned that the energy-dependent drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance, the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated. §Although MDR is currently the most understood mechanism of drug resistance, we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance. §It is clear that drug resistance is complex, and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy.

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Anticancer Drug Resistance

Advances in Molecular and Clinical Research

Информация за книгата

Пълно описание

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