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Книга Benzodiazepine-Based Drug Discovery Farzad Zamani

Benzodiazepine-Based Drug Discovery

Автор: Farzad Zamani, Esmail Doustkhah
Език: Английски език
Корици: С меки корици
Издател: Elsevier Science Publishing Co Inc
Наличност: Външен склад
Изпращаме след 14-21 дни
248.60 € 486.21 лв
Benzodiazepine-Based Drug Discovery covers benzodiazepines and benzothiazepines, which constitute tw...

Информация за книгата

Автор
Farzad Zamani, Esmail Doustkhah
Език
Английски език
Корици
Книга - С меки корици
Издадена
2022
страници
338
EAN
9780128245163
Enbook ID
33270885
Издател
Elsevier Science Publishing Co Inc
Теглоt
540
Размери
152 x 229

Пълно описание

Benzodiazepine-Based Drug Discovery covers benzodiazepines and benzothiazepines, which constitute two pivotal classes of heterocyclic compounds widely used as core structures of medicinal drugs for the treatment of depression, epilepsy, seizures and muscle spasms. 1,4-Benzodiazepine, 1,5-benzodiazepine, and 1,5-benzothiazepine are the most studied groups of benzodiazepines and benzothiazepines because of their outstanding potential biological activities. The importance of these privileged pharmacophores is not limited to the treatment of psychotic disorders because minor changes in the structures can generate various biological activities. They represent a wide range of therapeutic functions such as anticonvulsant, antianxiety, anti-depressant, antiviral, anti-HIV, anti-inflammatory, anticoagulant, anti-obesity, endothelin antagonist, cholecystokinin antagonist, and vasopressin receptor antagonist activities. These versatile skeletons are key components in synthesizing and screening analogues for novel applications in drug discovery. This book offers a broad range of recent developments and detailed coverage of synthesis and biological activities of the drugs based on bezodiazepine and benzothiazepine matrixes, and is an ideal reference guide to researchers working in organic and medicinal chemistry. Presents detailed coverage of chemical structures and practical synthetic methods of benzodiazepines and benzothiazepines in drug discoverCompiles detailed in vivo and in vitro biological activity data of 1,4-benzodiazepine- and 1,5-benzodiazepine-based drugs that will help researchers design and develop innovative drugsDiscusses promising avenues and potential challenges in the development of new benzodiazepines and benzothiazepines in medicinal drug synthesis

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