CD4 Molecule

Name: CD4 Molecule
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 9783642798009
Price: 105.32 EUR
Availability: InStock

Roles in T Lymphocytes and in HIV Disease

Автор: Dan R. Littman

Език:

Корици: С меки корици

Издател: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Наличност: Външен склад

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During the late 1970's the application of hybridoma technology led to an explosion in the discovery...

Информация за книгата

Автор

Dan R. Littman

Език

Английски език

Корици

Книга - С меки корици

Издадена

2011

страници

182

EAN

9783642798009

ISBN

9783642798009

Enbook ID

06620614

Издател

Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Теглоt

312

Размери

155 x 235 x 12

Пълно описание

During the late 1970's the application of hybridoma technology led to an explosion in the discovery and characterization of proteins expressed at the surface of hematopoietic cells. The understanding of T lymphocyte biology benefited enormously from this advance and from newly developed techniques for obtaining clonal T cells. Application of these methodologies resulted in the identification of the clonally restricted T cell antigen receptors (TCRs) and of a number of other molecules expressed more broadly on T cells. Among these, the CD4 and CD8 glycoproteins stood out because they were differentially expressed on distinct functional subsets of T lymphocytes. Moreover, blocking studies with monoclonal antibodies sug gested a functional role for CD4 and CD8 in T cell responses to antigen. Shortly thereafter, it was shown that T helper cells were the primary targets for the human immunodeficiency virus (HIV) and that CD4 serves as the viral receptor on these cells. These findings fueled an intense interest in CD4 during the last decade, in the hope that understanding the molecular nature of the HIV-CD4 interaction could hold the key to controlling AIDS.

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