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Colon Targeted Prodrug Approach

Name: Colon Targeted Prodrug Approach
Brand: LAP LAMBERT Academic Publishing
SKU: 9786204206684
Price: 34.66 EUR
Availability: InStock

Автор: Gaurav Tiwari, Man Singh

Език:

Корици: С меки корици

Издател: LAP LAMBERT Academic Publishing

Наличност: Външен склад

Изпращаме след 5-8 дни

34.66 € 67.79 лв

Nalidixic acid-Tryptophan conjugate was synthesized by coupling Nalidixic acid with glycine methyl e...

Информация за книгата

Автор

Gaurav Tiwari, Man Singh

Език

Английски език

Корици

Книга - С меки корици

Издадена

2021

страници

EAN

9786204206684

ISBN

6204206680

Enbook ID

37311968

Издател

LAP LAMBERT Academic Publishing

Теглоt

143

Размери

150 x 220 x 5

Пълно описание

Nalidixic acid-Tryptophan conjugate was synthesized by coupling Nalidixic acid with glycine methyl ester hydrochloride and characterized by melting point, thin layer chromatography, RM value, scanning electron microscopy, x-ray diffraction study and high performance liquid chromatography. The structure of prodrug was confirmed by analytical techniques, elemental analysis, fourier transform infrared spectroscopy, fourier transform nuclear magnetic resonance spectroscopy and mass spectroscopy. Preformulation studies revealed increased aqueous solubility with non significant change in lipophilicity of Nalidixic acid-Tryptophan conjugate than Nalidixic acid. In vitro reversion confirmed that the prodrug reversion was non significant in gastric environment, thus the objective of bypassing the GIT without any free drug release was achieved. However 67.83 % reversion of Nalidixic acid-Tryptophan conjugate to Nalidixic acid was observed in phosphate buffer pH 6.8 in presence of 20% w/v fresh rat fecal matter due to hydrolysis of amide linkage by amidase enzyme secreted by colonic microflora.