Computational Methods for Fragment Spectrum Interpretation

Name: Computational Methods for Fragment Spectrum Interpretation
Brand: VDM Verlag
SKU: 9783639228588
Price: 49.82 EUR
Availability: InStock

Computational Interpretation of Tandem MS Spectra Including Fragment Ions with Post-Translational Modifications

Автор: Jonathan Rameseder, Lennart Martens

Език:

Корици: С меки корици

Издател: VDM Verlag

Наличност: Външен склад

Изпращаме след 9-15 дни

49.82 € 97.44 лв

Post-translational modifications (PTMs) are of critical importance for a vast range of cellular proc...

Информация за книгата

Автор

Jonathan Rameseder, Lennart Martens

Език

Английски език

Корици

Книга - С меки корици

Издадена

2010

страници

EAN

9783639228588

ISBN

3639228588

Enbook ID

06830633

Издател

VDM Verlag

Теглоt

Размери

152 x 229 x 10

Пълно описание

Post-translational modifications (PTMs) are of critical importance for a vast range of cellular processes such as growth control and signal transduction. Mass spectrometry (MS) can shed light on the characteristics of PTMs to gain insight into the mechanisms of numerous diseases including cancer. However, interpretation of tandem MS spectra including fragment ions with PTMs from high-throughput experiments is a complex challenge. The high number and diversity of known PTMs as well as suboptimal quality of spectra compromise the identification of PTMs in MS experiments. In this book, an efficient algorithm for the computational interpretation of tandem MS spectra including fragment ions with PTMs is described. Information on both precursor and fragment ion level is utilized and an arbitrary number of PTMs is considered. A robust statistical noise intensity model is developed to compensate for low spectrum quality. Finally, the algorithm is successfully applied on the fragment spectra in the PRIDE proteomics data repository to render it suitable for statistical machine learning investigations.

Може също да ви хареса

Клиенти, които купиха тази книга, купиха също

Най-често търсени

Categories

Authors

Publishers

Продукти

Продукти

Най-често търсени

Categories

Authors

Publishers

Продукти

Продукти

Computational Methods for Fragment Spectrum Interpretation

Computational Interpretation of Tandem MS Spectra Including Fragment Ions with Post-Translational Modifications

Информация за книгата

Пълно описание

Може също да ви хареса

Клиенти, които купиха тази книга, купиха също