Development of antidiabetic formulation with cyclodextrins

Name: Development of antidiabetic formulation with cyclodextrins
Brand: LAP Lambert Academic Publishing
SKU: 9786202021883
Price: 33.02 EUR
Availability: InStock

Автор: Vasanti Suvarna, Pramila Chaubey, Mansi Chalke

Език:

Корици: С меки корици

Издател: LAP Lambert Academic Publishing

Наличност: Външен склад

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The aim of present investigation was to enhance solubility and dissolution of Nateglinide, poorly wa...

Информация за книгата

Автор

Vasanti Suvarna, Pramila Chaubey, Mansi Chalke

Език

Английски език

Корици

Книга - С меки корици

Издадена

2017

страници

EAN

9786202021883

Enbook ID

18257046

Издател

LAP Lambert Academic Publishing

Теглоt

102

Размери

150 x 220 x 3

Пълно описание

The aim of present investigation was to enhance solubility and dissolution of Nateglinide, poorly water soluble drug with cyclodextrin (CD). The binary system of Nateglinide with cyclodextrin was prepared by different techniques. The phase solubility diagram of exhibit AL type of isotherm, which indicates linear increase in solubility as a function of cyclodextrin. The dissolution rate was found to be more effective using spray drying method of complexation in comparison with physical mixing method n kneading method of complexation. The developed cyclodextrin tablet formulation of nateglinide showed better dissolution rate than that of marketed product. A suitable UV method for dissolution study was developed. A HPLC method for assay of developed formulation was developed.

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Development of antidiabetic formulation with cyclodextrins

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Пълно описание

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