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Diclofenac Potassium Tablet for Colon Targeting: Formulation

Name: Diclofenac Potassium Tablet for Colon Targeting: Formulation
Brand: LAP LAMBERT Academic Publishing
SKU: 9786206181217
Price: 40.24 EUR
Availability: InStock

Автор: Ravindra Jarag, Harinath More

Език:

Корици: С меки корици

Издател: LAP LAMBERT Academic Publishing

Наличност: 50% вероятност

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The present study was to formulate tablet of Diclofenac potassium using the hydrophilic polymer hydr...

Информация за книгата

Автор

Ravindra Jarag, Harinath More

Език

Английски език

Корици

Книга - С меки корици

Издадена

2023

страници

EAN

9786206181217

ISBN

6206181219

Enbook ID

43849048

Издател

LAP LAMBERT Academic Publishing

Теглоt

Размери

150 x 220 x 4

Пълно описание

The present study was to formulate tablet of Diclofenac potassium using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC), Hydroxypropyl Cellulose (HPC), Ethyl Cellulose(N22), Cross Povidone and Sodium Starch Glycolate as a superdisintegrants and Instacoat EN super II as a enteric coat to the colone specific tablet. A 33 randomized full factorial design, 3 level and 3 factors were used. The concentration of Hydroxy propyl cellulose (X1), concentration of HPMC K4M (X2) and concentration of Ethyl cellulose (X3) were selected as independent variables. The percentage drug release at 12 hours (Q12), percentage friability and hardness of tablet were selected as dependent variables for optimization study. The core, press coat tablets were compressed by rotatory tablet machine evaluated with different parameters like diameter, thickness, average weight, hardness, friability, kinetic release data. Hardness of tablets was found to be in the range of 7-8 kg/cm2. The enteric coated tablets containing diclofenac potassium released 38.12 % at the end of 12 hrs by in vitro release study.

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Diclofenac Potassium Tablet for Colon Targeting: Formulation

Информация за книгата

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