Eicosanoids and Radiation

Name: Eicosanoids and Radiation
Brand: Springer-Verlag New York Inc.
SKU: 9781461289708
Price: 178.1 EUR
Availability: InStock

Автор: Peter Polgar

Език:

Корици: С меки корици

Издател: Springer-Verlag New York Inc.

Наличност: Външен склад в ограничено количество

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Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging are...

Информация за книгата

Автор

Peter Polgar

Език

Английски език

Корици

Книга - С меки корици

Издадена

2012

страници

196

EAN

9781461289708

ISBN

146128970X

Enbook ID

02186744

Издател

Springer-Verlag New York Inc.

Теглоt

332

Размери

155 x 235 x 12

Пълно описание

Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin Ez (PGEz), prostacyclin (PGIz) and thromboxane Az (TXAz), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

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