Endogenous Retroviruses, Autoimmunity and Multiple Sclerosis

Name: Endogenous Retroviruses, Autoimmunity and Multiple Sclerosis
Brand: LAP Lambert Academic Publishing
SKU: 9783659146190
Price: 81.52 EUR
Availability: InStock

MSRV/HERV-W : Inflammatory and Immunological Actions

Автор: Christina Lomparski

Език:

Корици: С меки корици

Издател: LAP Lambert Academic Publishing

Наличност: Налично при издателя, по поръчка

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81.52 € 159.44 лв

Endogenous retroviruses (of the HERV-W family) represent about 8% (1%) of our genome. Their endogeno...

Информация за книгата

Автор

Christina Lomparski

Език

Английски език

Корици

Книга - С меки корици

Издадена

2012

страници

240

EAN

9783659146190

Enbook ID

06996678

Издател

LAP Lambert Academic Publishing

Теглоt

374

Размери

150 x 220 x 14

Пълно описание

Endogenous retroviruses (of the HERV-W family) represent about 8% (1%) of our genome. Their endogenous and exogenous forms (MSRV, Multiple Sclerosis-associated RetroVirus) can alter the regulation of the immune system and be involved in inflammatory and autoimmune pathologies (Multiple Sclerosis). The MSRV envelope protein (ENV) stimulates T lymphocytes by acting as a superantigen and interacts with monocytes and dendritic cells via membrane receptors, thereby provoking inflammatory cytokine production. The work presented in this thesis combines an in vitro cellular and molecular approach (immunological cascade from receptor interaction to pathology) with an in vivo validation using the mouse model Experimental Autoimmune Encephalomyelitis (EAE) in which the complete Freund's adjuvant can be replaced by ENV ; its effects are monitored by behavioural (clinical score), brain (MRI), cellular and molecular analysis. In order to create a transgenic mouse model expressing different ENVs (MSRV/HERV) ruled by different promoters, first steps of cloning have been done; behaviour, brain and immune system particularities of these mice shall be studied in futur works.

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Endogenous Retroviruses, Autoimmunity and Multiple Sclerosis

MSRV/HERV-W : Inflammatory and Immunological Actions

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Пълно описание

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