Formulation and Evaluation of Bilayer Tablet

Name: Formulation and Evaluation of Bilayer Tablet
Brand: LAP Lambert Academic Publishing
SKU: 9783659545962
Price: 65.79 EUR
Availability: InStock

For the Treatment of Gastric and Duodenal Ulcer

Автор: Kiran Dudhat, Naisarg Pujara

Език:

Корици: С меки корици

Издател: LAP Lambert Academic Publishing

Наличност: Външен склад

Изпращаме след 5-8 дни

65.79 € 128.68 лв

Pantoprazole sodium and ondansetron hydrochloride are commonly prescribed for the treatment of gastr...

Информация за книгата

Автор

Kiran Dudhat, Naisarg Pujara

Език

Английски език

Корици

Книга - С меки корици

Издадена

2014

страници

176

EAN

9783659545962

Enbook ID

02765571

Издател

LAP Lambert Academic Publishing

Теглоt

268

Размери

152 x 229 x 10

Пълно описание

Pantoprazole sodium and ondansetron hydrochloride are commonly prescribed for the treatment of gastric and duodenal ulcer associated with vomiting. Both the drugs having short biological half-life, so it leads frequent administration which may lead to patient incompliance. Further the pantoprazole Na is acid labile molecules and having irritation effect to stomach mucosa, so it needs to be given in the form of enteric formulation. While in case of ondansetron HCl have narrow therapeutic window in the stomach hence to prepare gastro-retentive formulation which offers advantages like better patient compliance and would lower the total cost of therapy. For the floating layer, influence of polymers and NaHCO3 with the application of 32 factorial design to optimization, for improving the sustain release of ondansetron HCl. It was prepared by wet granulation method and evaluated this layer using in vitro buoyancy and in vitro drug release study. For the enteric layer, influence of polymers and solvent system was preventing the drug release in the stomach environment with targeting at duodenal ulcers. It was prepared by intra-granulation method and evaluating by conducting in vitro study

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Formulation and Evaluation of Bilayer Tablet

For the Treatment of Gastric and Duodenal Ulcer

Информация за книгата

Пълно описание

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