Genome - Kinome

Name: Genome - Kinome
Brand: VDM Verlag Dr. Müller
SKU: 9783639137774
Price: 60.99 EUR
Availability: InStock

Utilize cross species genomic information to develop a species specific tool for global kinome analysis

Автор: Shakiba Jalal

Език:

Корици: С меки корици

Издател: VDM Verlag Dr. Müller

Наличност: Налично при издателя, по поръчка

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Kinases belong to one of the most biologically§significant enzyme classes. The development of§analyt...

Информация за книгата

Автор

Shakiba Jalal

Език

Английски език

Корици

Книга - С меки корици

Издадена

2009

страници

132

EAN

9783639137774

Enbook ID

06822438

Издател

VDM Verlag Dr. Müller

Размери

220

Пълно описание

Kinases belong to one of the most biologically§significant enzyme classes. The development of§analytical techniques for characterization of kinase§activity, in particular at a global scale, is a§central priority for proteomic and cell biology§researchers.§In order to facilitate global analysis of cellular§phosphorylation, a new paradigm of microarray§technology which focuses on analysis of total§cellular kinase activity, kinome, has emerged in the§past few years.§As the specificity of many kinases is dictated§primarily by recognition of residues immediately§surrounding the site of phosphorylation a logical§methodology is to employ peptides§representing these immediate sequences as§experimental substrates. Microarray chips carrying§hundreds of such substrate targets have been§developed for human kinome analysis, however,§lack of similar tools for species outside research§mainstream has limited kinome analysis in§these species. This work describes a methodology to§create species specific peptide arrays. A case study§is carried out to analyze Toll Like Receptor (TLR)§signaling pathways in bovine monocytes.

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Genome - Kinome

Utilize cross species genomic information to develop a species specific tool for global kinome analysis

Информация за книгата

Пълно описание

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