Immune System and the Developing Brain

Автор: Staci Bilbo, Jaclyn Schwarz

Език:

Корици: С меки корици

Издател: Morgan & Claypool Publishers

Наличност: Външен склад

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The developing brain is exquisitely sensitive to both endogenous and exogenous signals which direct...

Информация за книгата

Автор

Staci Bilbo, Jaclyn Schwarz

Език

Английски език

Корици

Книга - С меки корици

Издадена

2011

страници

128

EAN

9781615043514

ISBN

1615043519

Enbook ID

04839057

Издател

Morgan & Claypool Publishers

Теглоt

240

Размери

191 x 234 x 7

Пълно описание

The developing brain is exquisitely sensitive to both endogenous and exogenous signals which direct or significantly alter the developmental trajectory of cells, neural circuits, and associated behavioral outcomes for the life of the individual. Contrary to initial dogma that the brain is one of the few organs within the body that is immune-privileged, evidence indicates that the immune system has a critical role in brain function during development as well as during sickness and health in adulthood. Microglia are the primary immune cells within the brain, and they are in constant communication with the peripheral immune system and surrounding cell types within the brain. We describe the important role of the immune system, including microglia, during brain development, and discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, and cognition. Growing evidence indicates that there is a strong link between many neuropsychiatric disorders and immune dysfunction, with a distinct etiology in neurodevelopment. Thus, understanding the role of the immune system and immune activation during the critical period of brain development is a necessary step toward understanding the potential origins of these devastating disorders. Table of Contents: Introduction / The Immune Response / Brain-Immune Communication / Microglia Are Immune Cells of the Brain / The Functional Role of Microglia and Immune Molecules in Neurodevelopment / Early-Life Programming of Brain and Behavior: A Critical Role for the Immune System / Commonly Used Models of Early Life Immune Activation in the Rodent / Early Life Immune Activation and Cognitive Impairment in Adulthood / Mechanisms Underlying the Enduring Changes in Neuroimmune Function Caused by Early Life Infection / Toll-Like Receptors and Immune Activation During Early Brain Development / Environmental Triggers of TLR Activation: Long-Term Programming of Brain and Behavior / Future Directions to Understanding Immune Function and Brain Development / References

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Immune System and the Developing Brain

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