Interactions between membrane transporters and phospholipids

Name: Interactions between membrane transporters and phospholipids
Brand: VDM Verlag
SKU: 9783639136708
Price: 50.95 EUR
Availability: InStock

Автор: Pierre Hakizimana

Език:

Корици: С меки корици

Издател: VDM Verlag

Наличност: Налично при издателя, по поръчка

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Highly solved crystal structures and a wealth of§biochemical data are now available for an increasin...

Информация за книгата

Автор

Pierre Hakizimana

Език

Английски език

Корици

Книга - С меки корици

Издадена

2009

страници

EAN

9783639136708

ISBN

3639136705

Enbook ID

06822344

Издател

VDM Verlag

Теглоt

145

Размери

152 x 229 x 6

Пълно описание

Highly solved crystal structures and a wealth of§biochemical data are now available for an increasing§number of membrane proteins. However, the question of§how lipid molecules interact with integral membrane§proteins and regulate their structure and function in§biological membranes remains unsatisfactorily addressed. §This book discusses the functional mechanisms§of membrane proteins in general and the effect of the§surrounding lipidic environment, in the context of§recent developments in the field. Recent experimental§investigations on the proton gradient-driven§multidrug transporter LmrP are also discussed. Using§this membrane protein as a model, we demonstrated§that the protein structure and function was depending§on the phosphatidylethanolamine (PE) headgroup. We§then showed that a negatively charged residue, Asp68,§could participate in the interaction with PE and that§such interaction is required for proper activity and§structure of the protein. Because Asp-68 belongs to a§highly conserved motif of the Major Facilitator§Superfamily (MFS) , this interaction might be a§general feature of these transporters that is§involved in proton gradient sensing and lipid dependence.

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Interactions between membrane transporters and phospholipids

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