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Malaria Immunopathology

Name: Malaria Immunopathology
Brand: VDM Verlag
SKU: 9783639136333
Price: 70.14 EUR
Availability: InStock

Signaling and Cellular Mechanisms Involved in Hemozoin-inducible Proinflammatory Events

Автор: Maritza Jaramillo

Език:

Корици: С меки корици

Издател: VDM Verlag

Наличност: Налично при издателя, по поръчка

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Plasmodium is the causative agent of malaria, the §most deadly parasitic infection worldwide. §Patho...

Информация за книгата

Автор

Maritza Jaramillo

Език

Английски език

Корици

Книга - С меки корици

Издадена

2009

страници

172

EAN

9783639136333

ISBN

3639136330

Enbook ID

06822311

Издател

VDM Verlag

Теглоt

259

Размери

152 x 229 x 10

Пълно описание

Plasmodium is the causative agent of malaria, the §most deadly parasitic infection worldwide. §Pathogenesis of the disease involves an exacerbated §immunological response; however, the role of §parasite components remains largely unexplored. The §current study was designed to assess the §contribution of hemozoin (HZ), a metabolic product §of Plasmodium, to the inflammatory events §associated to malaria. HZ was found to induce §various macrophage functions (e.g. chemokine and §nitric oxide production) through specific signaling §pathways. Importantly, the proinflammatory activity §of HZ was demonstrated in vivo (e.g. leukocytosis,§chemokine and cytokine release) using a murine §model. These findings support the idea that HZ §participates in inflammatory mediator overproduction §during malaria and therefore, it could be a key §component in the development of the disease. HZ §might emerge as an attractive target to design new §therapeutic approaches against malaria to prevent §millions of deaths. This book should be especially §useful to graduate students and researchers §interested in understanding the molecular and §cellular basis of malaria pathogenesis.

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Malaria Immunopathology

Signaling and Cellular Mechanisms Involved in Hemozoin-inducible Proinflammatory Events

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