Microcantilever sensor systems have recently §attracted much attention as a promising and highly §sensitive approach to "label-free" detection of §biomolecules. These techniques have the potential to §be developed into a robust framework for disease §diagnostics, genomics research, and drug discovery. §§In this book, a wide range of biomolecular systems §including DNA nanomotor, polymer brushes and §proteins have been investigated using §microcantilever systems for biosensing and §nanoactuation applications. §§Both single cantilever and multiple cantilever array §detection systems were introduced. In particular, §the technical details regarding the design, §construction and calibration of a microcantilever §detection system were given to provide some general §introductory information for microcantilever §beginners. Microcantilever sensor systems have recently §attracted much attention as a promising and highly §sensitive approach to "label-free" detection of §biomolecules. These techniques have the potential to §be developed into a robust framework for disease §diagnostics, genomics research, and drug discovery. §In this book, a wide range of biomolecular systems §including DNA nanomotor, polymer brushes and §proteins have been investigated using §microcantilever systems for biosensing and §nanoactuation applications. §Both single cantilever and multiple cantilever array §detection systems were introduced. In particular, §the technical details regarding the design, §construction and calibration of a microcantilever §detection system were given to provide some general §introductory information for microcantilever §beginners.