Novartis Foundation Symposium 287 - Mitochondrial Biology - New Perspectives

Автор: Derek J. Chadwick

Език:

Корици: С твърди корици

Издател: John Wiley & Sons Inc

Наличност: Външен склад в ограничено количество

Изпращаме след 11-15 дни

209.91 € 410.54 лв

With the recent renaissance in mitochondrial biology and increasing recognition of their role in man...

Информация за книгата

Автор

Derek J. Chadwick

Език

Английски език

Корици

Книга - С твърди корици

Издадена

2007

страници

254

EAN

9780470066577

ISBN

0470066571

Enbook ID

04879401

Издател

John Wiley & Sons Inc

Теглоt

536

Размери

163 x 237 x 17

Пълно описание

With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail. Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson's, Huntington's and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.

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