Книга Mitochondrial Oxidative Phosphorylation Bernhard Kadenbach

Mitochondrial Oxidative Phosphorylation

Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology

Автор: Bernhard Kadenbach
Език: Английски език
Корици: С твърди корици
Наличност: Външен склад в ограничено количество
Изпращаме след 13-18 дни
230.15 450.14 лв
This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxid...

Информация за книгата

Автор
Език
Английски език
Корици
Книга - С твърди корици
Издадена
2012
страници
372
EAN
9781461435723
ISBN
1461435722
Enbook ID
01427802
Теглоt
736
Размери
240 x 161 x 26

Пълно описание

This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.

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