Mixed substrate dynamics in Pichia pastoris

Name: Mixed substrate dynamics in Pichia pastoris
Brand: VDM Verlag
SKU: 9783639345797
Price: 50.82 EUR
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Автор: Arne Seifert

Език:

Корици: С меки корици

Издател: VDM Verlag

Наличност: Налично при издателя, по поръчка

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The early quantitative characterization of possible production hosts is a key element in the develop...

Информация за книгата

Автор

Arne Seifert

Език

Английски език

Корици

Книга - С меки корици

Издадена

2011

страници

EAN

9783639345797

ISBN

3639345797

Enbook ID

06841094

Издател

VDM Verlag

Теглоt

113

Размери

152 x 229 x 4

Пълно описание

The early quantitative characterization of possible production hosts is a key element in the development of knowledge based biotechnological processes. Despite of scale independent parameters like substrate uptake rates, production rates, maximum growth rates and yields, the performance on mixed substrates, as they occur for example during induction of recombinant protein production, is of great interest. In the present work, pulse and shift experiments with glycerol, glucose, malate, pyruvate and acetate were performed in chemostat cultures of the methylotrophic yeast Pichia pastoris. This allowed the quantitative examination of mixed substrate dynamics and the adaptation to higher growth rates. Different on- and off-line methods were used for a quantitative monitoring of the fermentation process and as input variables to mass balances. Elemental balances in combination with a statistical test for validation of the results were used for data reconciliation. Based on the results, the author discusses the pulsed substances towards their repressive, additive or competitive behaviour as mixed substrates and their effect on the yeasts metabolism.

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Mixed substrate dynamics in Pichia pastoris

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