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Книга Molecular Dynamic Simulation Studies Vijay Raj Bollapalli

Molecular Dynamic Simulation Studies

Автор: Vijay Raj Bollapalli, V. Raghavendra Rao Morusupalli
Език: Английски език
Корици: С меки корици
Издател: SPS
Наличност: Външен склад
Изпращаме след 5-8 дни
82.26 € 160.88 лв
Mdm2 has been identified as a p53 interacting protein towards represses p53 transcriptional activity...

Информация за книгата

Автор
Vijay Raj Bollapalli, V. Raghavendra Rao Morusupalli
Език
Английски език
Корици
Книга - С меки корици
Издадена
2017
страници
220
EAN
9783330650909
ISBN
3330650907
Enbook ID
16123219
Издател
SPS
Теглоt
344
Размери
150 x 220 x 13

Пълно описание

Mdm2 has been identified as a p53 interacting protein towards represses p53 transcriptional activity.Mdm2 achieves this repression by binding to P53 and blocking the N- terminal transactivation domain of p53. Mdm2 is a p53 responsive gene that is; its transcription can be activated by p53. When p53 is stabilized, the transcription of Mdm2 is also induced, resulting in higher mdm2 protein levels causing recognition and repair, transcription regulation problems leading to cancer. Thus inhibiting the mdm2- p53 interactions has been proven to be most promising approach for cancer therapy.

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