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Neurodegeneration

Metallostasis and Proteostasis

Автор: Danilo Milardi, Enrico Rizzarelli

Език:

Корици: С твърди корици

Издател: Royal Society Of Chemistry

Наличност: Външен склад

Изпращаме след 14-21 дни

165.96 € 324.58 лв

Since Alois Alzheimer described the results of his postmortem studies in 1906, significant strides h...

Информация за книгата

Автор

Danilo Milardi, Enrico Rizzarelli

Език

Английски език

Корици

Книга - С твърди корици

Издадена

2011

страници

270

EAN

9781849730501

ISBN

1849730504

Enbook ID

05107219

Издател

Royal Society Of Chemistry

Теглоt

566

Размери

156 x 240 x 22

Пълно описание

Since Alois Alzheimer described the results of his postmortem studies in 1906, significant strides have been made in understanding the pathogenesis of neurodegenerative diseases. Substantial evidence has accumulated indicating that diverse neurodegenerative disorders might share a common pathological mechanism: the misfolding, aggregation and accumulation of proteins (termed "amyloid") in the brain. Metal ions have long been thought to catalyze protein misfolding initiating a cascade of events resulting in oxidative damage and neurodegeneration. They have, consequently, been seen as a suitable pharmacological target. However, drugs aimed at simply removing excess metals or interfering in amyloid deposition were unsuccessful and scientists have been forced to review the classical hypothesis. The latest advances suggest that deficiencies in protein homeostasis may lead to cell dysfunction and disease. Furthermore, small molecules with the potential to control metal homeostasis, or metallostasis, are expected to provide the framework for the design of novel proteostasis regulators. This book provides an up-date on the latest developments in this fast moving field. Traditional views concerning the relationship between the physio-pathological cycles of copper, zinc, iron, aluminium and the evolution of life, are compared with emerging ideas in the neuroscience of metal ions. Topics covered emphasize the importance of metals and oxidation chemistry to neuroscientists as well as providing a wider, multidisciplinary background to chemists who are attracted by these fascinating subjects. The text starts with a chapter on chemical evolution, the brain and metallomics which describes the brain's natural defences to adverse conditions. It then goes on to cover the chemistry and biology of proteostasis, environmental factors, and the role played by membranes in protein misfolding. The remaining chapters cover the role of metals and oxidative stress in Alzheimer's Disease, Parkinsonism, ALS and other neurodegenerative diseases. The book is suitable for academics, those working in industry, and postgraduate students.

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Neurodegeneration

Metallostasis and Proteostasis

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