Polyamine Drug Discovery

Автор: Patrick Woster

Език:

Корици: С твърди корици

Издател: Royal Society Of Chemistry

Наличност: Външен склад в ограничено количество

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Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. A...

Информация за книгата

Автор

Patrick Woster

Език

Английски език

Корици

Книга - С твърди корици

Издадена

2011

страници

302

EAN

9781849731904

ISBN

184973190X

Enbook ID

04416368

Издател

Royal Society Of Chemistry

Теглоt

600

Размери

239 x 161 x 22

Пълно описание

Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. Aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infection. A number of validated drug targets have been identified, including enzymes in the polyamine biosynthetic and catabolic pathways and the S-adenosylmethionine synthetic and salvage pathways. Polyamine Drug Discovery is the first comprehensive volume to cover all aspects of the design and development of potential therapeutics targeting polyamine metabolism. The book details research progress from 1975 to the present date and discusses the design and use of polyamine metabolism inhibitors as therapeutic agents. Various polyamine-containing drugs are described that can be used in chemotherapy, and as treatments for infections including trypanosomiasis, leishmaniasis and malaria. Finally, the roles of polyamine analogues in chemoprevention, polyamine-containing vectors for gene delivery, and the design of polyamine-based epigenetic modulators are detailed. Each chapter addresses a different aspect of polyamine drug discovery and all are written by medicinal and biological chemists with particular expertise in developing agents that modulate polyamine metabolism or function. The book will increase the visibility of polyamine drug discovery among pharmaceutical researchers and provide a valuable reference for everyone working in the field.

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