Книга Post-Structural Genomics Zhiyan Fu

Post-Structural Genomics

Correlate Protein Sequence, Structure, and Function

Автор: Zhiyan Fu
Език: Английски език
Корици: С меки корици
Издател: VDM Verlag
Наличност: Външен склад
Изпращаме след 9-15 дни
59.74 116.83 лв
One of the goals the post-genomic era is to use§protein sequence and structure data to learn about§t...

Информация за книгата

Автор
Език
Английски език
Корици
Книга - С меки корици
Издадена
2008
страници
132
EAN
9783639113167
ISBN
3639113160
Enbook ID
06820202
Издател
Теглоt
194
Размери
155 x 227 x 9

Пълно описание

One of the goals the post-genomic era is to use§protein sequence and structure data to learn about§the function of these proteins in normal and disease§states. In the omics era, computational methods§constitute a valuable tool, because they can easily§process large amounts of data and provide useful and§instant information relevant in biomedical research.§This book described using computational approaches to§study the effects of genetic mutations in proteins,§with the general aim of correlating protein sequence,§structure, and function. Our works focus on§identifying whether genotype/phenotype relationship§can be learned from protein sequence and structuralinformation, whether protein structure prediction§methods are accurate enough to provide useful§information when the experimental structures are not§available, and finally to combine this information to§predict and understand the effect of mutations on§clinical phenotype and drug responses. The approaches§developed in this work enable a systematic,§comprehensive, and quantitative analysis of§disease-related mutations and establish a paradigm to§study genotype/phenotype correlations.

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