Protein-protein Recognition

Автор: Colin Kleanthous

Език:

Корици: С меки корици

Издател: Oxford University Press

Наличност: Налично при издателя, по поръчка

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The purpose of Protein-Protein Recognition is to bring together concepts and systems pertaining to p...

Информация за книгата

Автор

Colin Kleanthous

Език

Английски език

Корици

Книга - С меки корици

Издадена

2000

страници

342

EAN

9780199637607

ISBN

0199637601

Enbook ID

04534165

Издател

Oxford University Press

Теглоt

700

Размери

190 x 244 x 20

Пълно описание

The purpose of Protein-Protein Recognition is to bring together concepts and systems pertaining to protein-protein interactions in a single unifying volume. In the light of the information from the genome sequencing projects and the increase in structural information it is an opportune time to try to make generalizations about how and why proteins form complexes with each other. The emphasis of the book is on heteromeric complexes (complexes in which each of the components can exist in an unbound state) and will use well-studied model systems to explain the processes of forming complexes. After an introductory section on the kinetics, thermodynamics, analysis, and classification of protein-protein interactions, weak, intermediate, and high affinity complexes are dealt with in turn. Weak affinity complexes are represented by electron transfer proteins and integrin complexes. Anti-lysozyme antibodies, the MHC proteins and their interactions with T-cell receptors, and the protein interactions of eukaryotic signal transduction are the systems used to explain complexes with intermediate affinities. Finally, tight binding complexes are represented by the interaction of protein inhibitors with serine proteases and by nuclease inhibitor complexes. Throughout the chapters common themes are the technologies which have had the greatest impact, how specificity is determined, how complexes are stabilized, and medical and industrial applications.

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