Pyrazoline Derivatives as Antitubercular Agents

Name: Pyrazoline Derivatives as Antitubercular Agents
Brand: LAP Lambert Academic Publishing
SKU: 9783848406340
Price: 51.02 EUR
Availability: InStock

Synthesis, Characterization & Evaluation of Some Novel Pyrazoline Derivatives

Автор: Vaibhav Jain, Priyal Jain, Surendra Jain

Език:

Корици: С меки корици

Издател: LAP Lambert Academic Publishing

Наличност: Налично при издателя, по поръчка

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51.02 € 99.78 лв

Mycobacterium tuberculosis (MTB), the pathogenic agent of tuberculosis (TB), is responsible for the...

Информация за книгата

Автор

Vaibhav Jain, Priyal Jain, Surendra Jain

Език

Английски език

Корици

Книга - С меки корици

Издадена

2012

страници

EAN

9783848406340

Enbook ID

06974974

Издател

LAP Lambert Academic Publishing

Теглоt

153

Размери

150 x 220 x 6

Пълно описание

Mycobacterium tuberculosis (MTB), the pathogenic agent of tuberculosis (TB), is responsible for the death of 2 3 million people annually and for a global economic toll of $12 billion each year. Thus, there is an urgent need to develop new therapeutics for tuberculosis, to reduce the duration of treatment and to provide a more effective therapy for MDR TB and for latent tuberculosis infection. In the present investigation, a series of 4-(4-(dimethylamino) benzyl)-3-methyl-1H-pyrazol-5(4H)-one analogues of pyrazole were synthesized by cyclization of mannich base with hydrazine hydrate. The nitrogen functionality of 4-(4-(dimethylamino) benzyl)-3-methyl-1H-pyrazol-5(4H)-one was alkylated with different halogenated alkylated substituted chain in the presence of base. The chemical structure of compounds were proved by IR, MASS, 1HNMR spectroscopy data and elemental analysis. . The antitubercular activity of these compounds were evaluated by microdilution method against M. Tuberculosis H37Rv micobactrium strain of M. Tuberculosis compared with standard INH, RIF & ETM.

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Pyrazoline Derivatives as Antitubercular Agents

Synthesis, Characterization & Evaluation of Some Novel Pyrazoline Derivatives

Информация за книгата

Пълно описание

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