Setd6

Name: Setd6
Brand: Sudwestdeutscher Verlag Fur Hochschulschriften AG
SKU: 9783838105758
Price: 64.04 EUR
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A Novel Histone Lysine Mono-Methyltransferase

Автор: Mario Richter

Език:

Корици: С меки корици

Издател: Sudwestdeutscher Verlag Fur Hochschulschriften AG

Наличност: Външен склад

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In this work we characterize a novel histone lysine §mono-methyltransferase called Setd6. By enzymat...

Информация за книгата

Автор

Mario Richter

Език

Английски език

Корици

Книга - С меки корици

Издадена

2009

страници

132

EAN

9783838105758

ISBN

3838105753

Enbook ID

07064947

Издател

Sudwestdeutscher Verlag Fur Hochschulschriften AG

Теглоt

186

Размери

152 x 229 x 7

Пълно описание

In this work we characterize a novel histone lysine §mono-methyltransferase called Setd6. By enzymatic §assays we demonstrate that this protein is capable §of modifying histone H1, H2A, H3 and H4. For all but §the linker histone H1 we furthermore determine the §exact residue methylated. In mouse NIH 3T3 cells a §reduction of the Setd6 protein level leads to a §misregulation of a set of genes including several §that are important for the regulation of §differentiation and cell line commitment. Amongst §those is a segregated co-regulator of the Wnt §signaling pathway. In immunoprecipitation §experiments we identify specific interactors of §Setd6 in murine immortalized fibroblasts and murine §embryonic stem cells. Again we find proteins that §are important for the Wnt signaling pathway. Taken §together the enzymatic activity and the in cell §results we conclude that we identified a novel §histone lysine mono-methyltransferase possibly §involved in the maintenance of cell line identity §and acting as antagonist of the histone §acetyltransferase Tip60 as both enzymes target the §exact same residues.

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Setd6

A Novel Histone Lysine Mono-Methyltransferase

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