Stem cells have a strong potential in developing better diagnostic, treatment and preventive strategies in SARS-CoV-2 infection. Both hematopoietic and mesenchymal stem cells are critical to better understand the response of immune system to coronavirus infection in both healthy and co-morbid conditions in the development of effective vaccines and immunotherapies. Stem Cells and COVID-19 presents up-to-date knowledge on the effect of hematopoietic and mesenchymal stem cells to combat SARS-CoV-2 infection in its diagnosis, treatment and prevention, critically discuss the challenges, highlight outstanding questions and future perspectives. Written by global experts in the field for both pre-clinical and clinical practitioners. Focuses on diagnosis, treatment and prevention Presents different aspects to enable researchers in the field to move toward designing novel therapeutics in the treatment of COVID-19 Provides coverage of the challenges and future perspectives in this fast-moving field