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Tumor Suppressor Par-4

Name: Tumor Suppressor Par-4
Brand: Springer Nature Switzerland AG
SKU: 9783030735715
Price: 178.8 EUR
Availability: InStock

Structural Features, Molecular Mechanisms and Function

Автор: Vivek M. Rangnekar

Език:

Корици: С твърди корици

Издател: Springer Nature Switzerland AG

Наличност: Външен склад

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178.80 € 349.70 лв

Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar's...

Информация за книгата

Автор

Vivek M. Rangnekar

Език

Английски език

Корици

Книга - С твърди корици

Издадена

2022

страници

323

EAN

9783030735715

ISBN

3030735710

Enbook ID

37628728

Издател

Springer Nature Switzerland AG

Теглоt

670

Размери

155 x 235 x 24

Пълно описание

Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar's laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule's structural features, key functional domains, regulation and relevant basic and clinical/translational facets.